Publikationen der letzten 5 Jahre

Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling.
Gurnik S*, Devraj K*, Macas J, Yamaji M, Starke J, Scholz A, Sommer K, Di Tacchio M, Vutukuri R, Beck H, Mittelbronn M, Foerch C, Pfeilschifter W, Liebner S, Peters KG, Plate KH*, Reiss Y*.  
Acta Neuropathol. 2016 Mar 1.  *equal contribution

Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma.
Scholz A*, Harter PN*, Cremer S*, Yalcin BH, Gurnik S, Yamaji M, Di Tacchio M, Sommer K, Baumgarten P, Bähr O, Steinbach JP, Trojan J, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Braun C, Schittenhelm J, Frueh JT, Ullrich E, Mittelbronn M, Plate KH*, Reiss Y*.
EMBO Mol Med. 2016; 8(1):39-57. *equal contribution

The angiopoietin—tie system: common signaling pathways for angiogenesis, cancer, and inflammation.
Reiss Y, Scholz A, Plate KH.
Springer: Endothel Signal Dev Dis. 2015; 13: 313 – 328. (Review)

Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation.
Scholz A, Plate KH, Reiss Y.  
Ann N Y Acad Sci. 2015; 1347:45-51. (Review)

Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells.
Korff T, Ernst E, Nobiling R, Feldner A, Reiss Y, Plate KH, Fiedler U, Augustin HG, Hecker M.
Cardiovasc Res. 2012 Jun 1;94(3):510-8. Epub 2012 Apr 14.

Angiopoietin-2 promotes myeloid cell infiltration in a β₂-integrin-dependent manner.
Scholz A, Lang V, Henschler R, Czabanka M, Vajkoczy P, Chavakis E, Drynski J, Harter PN, Mittelbronn M, Dumont DJ, Plate KH, Reiss Y.
Blood. 2011 Nov 3;118(18):5050-9. Epub 2011 Aug 25.

Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion.
Coffelt SB, Chen YY, Muthana M, Welford AF, Tal AO, Scholz A, Plate KH, Reiss Y, Murdoch C, De Palma M, Lewis CE.
J Immunol. 2011 Apr 1;186(7):4183-90. Epub 2011 Mar 2.

Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions.
Coffelt SB, Tal AO, Scholz A, De Palma M, Patel S, Urbich C, Biswas SK, Murdoch C, Plate KH, Reiss Y, Lewis CE.
Cancer Res. 2010 Jul 1;70(13):5270-80. Epub 2010 Jun 8.

Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells.
Doebele C, Bonauer A, Fischer A, Scholz A, Reiss Y, Urbich C, Hofmann WK, Zeiher AM, Dimmeler S.
Blood. 2010 Jun 10;115(23):4944-50. Epub 2010 Mar 18.

Reiss Y.
Recent Results Cancer Res. 2010;180:3-13. Review.

Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice.
Bhandarkar SS, Jaconi M, Fried LE, Bonner MY, Lefkove B, Govindarajan B, Perry BN, Parhar R, Mackelfresh J, Sohn A, Stouffs M, Knaus U, Yancopoulos G, Reiss Y, Benest AV, Augustin HG, Arbiser JL.
J Clin Invest. 2009 Aug;119(8):2359-65. doi: 10.1172/JCI33877. Epub 2009 Jul 13.

Switching of vascular phenotypes within a murine breast cancer model induced by angiopoietin-2.
Reiss Y, Knedla A, Tal AO, Schmidt MH, Jugold M, Kiessling F, Burger AM, Wolburg H, Deutsch U, Plate KH.
J Pathol. 2009 Mar;217(4):571-80.

Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes.
Pfaff D, Héroult M, Riedel M, Reiss Y, Kirmse R, Ludwig T, Korff T, Hecker M, Augustin HG.
J Cell Sci. 2008 Nov 15;121(Pt 22):3842-50. Epub 2008 Oct 28.

Flt-1 signaling in macrophages promotes glioma growth in vivo.
Kerber M, Reiss Y, Wickersheim A, Jugold M, Kiessling F, Heil M, Tchaikovski V, Waltenberger J, Shibuya M, Plate KH, Machein MR.
Cancer Res. 2008 Sep 15;68(18):7342-51.